Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets

In this report, we demonstrate that mouse platelets express full-length SykL and the previously described shorter isoform SykS, but lack other shorter isoforms, whereas human platelets express predominantly SykL. These results both indicate a possible role of alternative Syk splicing in the regulation of receptor signaling in mouse platelets and a difference between signaling regulation in mouse and human platelets.PMID:37661351 | DOI:10.1080/09537104.2023.2249549

Source: Platelets - September 4, 2023 Category: Hematology Authors: Pankaj Kumar Singh Carol A Dangelmaier Hymavathi Reddy Vari Alexander Y Tsygankov Satya P Kunapuli Source Type: research