Darier disease: A fold (intertriginous) dermatosis

Darier disease, also known as Darier-White disease, is characterized by yellow to brown, oily keratotic papules and plaques in the seborrheic areas of the face and chest. This disorder may show different clinical manifestations, such as palmoplantar pits and nail abnormalities. The trigger factors are mechanical trauma, heat, humidity, ultraviolet B, and pyogenic infections. The disease usually becomes apparent in the second decade of life. The ATP2 A2 (SERCA2) gene mutation was detected in all patients.

Source: Clinics in Dermatology - June 6, 2015 Category: Dermatology Authors: Burhan Engin, Zekayi Kutlubay, Emine Erkan, Yalçın Tüzün Source Type: research