Non-invasive daily profiles of tissue adrenal steroids

Nature Reviews Endocrinology, Published online: 11 September 2023; doi:10.1038/s41574-023-00901-9In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrometry enabled the building of a 24-h high-resolution profile of adrenal steroids in the tissue by sampling interstitial fluid in 214 healthy volunteers. Daily and ultradian variations of eight free steroids, including cortisol and aldosterone, have been demonstrated, which opens new diagnostic perspectives for endocrine diseases.

Source: Nature Reviews Endocrinology - September 11, 2023 Category: Endocrinology Authors: Fid éline Bonnet-Serrano J érôme Bertherat Source Type: research