The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell

Glomeruli stand at the center of nephrons to accomplish filtration and albumin interception.Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) and stromal cell-derived factor 1 α (SDF-1α), a ligand of CXCR4, were evidently upregulated in mesangial cells following the progression of podocyte injury.

Source: Translational Research - September 9, 2023 Category: Research Authors: Qinyu Wu, Shan Zhou, Dan Xu, Ping Meng, Qiurong Chen, Xiaoxu Wang, Xiaolong Li, Shuangqin Chen, Huiyun Ye, Wenting Ye, Yabing Xiong, Jiemei Li, Jinhua Miao, Weiwei Shen, Xu Lin, Fan Fan Hou, Youhua Liu, Yunfang Zhang, Lili Zhou Source Type: research