Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome

AbstractA progeroid family was found to harbor a pathogenic variant in theCASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype comprised of earlier onset of common aging diseases, supporting inflammaging as a potential common disease mechanism of progeroid syndromes and possibly normative aging.

Source: AGE - August 21, 2023 Category: Geriatrics Source Type: research