Metabolic control by AMPK in white adipose tissue

Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00164-9. doi: 10.1016/j.tem.2023.08.011. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.PMID:37673765 | DOI:10.1016/j.tem.2023.08.011
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research