Superficial and Bullous Neutrophilic Dermatoses

Sneddon –Wilkinson disease (SWD), IgA pemphigus, and bullous systemic lupus erythematosus (BSLE) are superficial and bullous neutrophilic dermatoses. They are all characterized by sterile neutrophilic infiltrate but differ in the level of skin affected and presence of autoantibodies. Both SWD and IgA pemp higus present with grouped flaccid pustules and have epidermal involvement; it is unclear whether they are distinct or exist on a spectrum of the same disease. IgA pemphigus is distinguished from SWD by positive direct immunofluorescence showing intercellular IgA deposition. BSLE presents with tense bullae, dermal neutrophilic infiltrate, and direct immunofluorescence showing linear IgG deposition along the dermal–epidermal junction.

Source: Dermatologic Clinics - September 7, 2023 Category: Dermatology Authors: Priya Manjaly, Katherine Sanchez, Samantha Gregoire, Sophia Ly, Kanika Kamal, Arash Mostaghimi Source Type: research