Beyond rational —biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes

In contrast to modern rational metabolic engineering, classical strain development strongly relies on random mutagenesis and screening for the desired production phenotype. Nowadays, with the availability of b...

Source: BMC Biology - September 4, 2023 Category: Biology Authors: Philipp T. Baumann, Michael Dal Molin, Hannah Aring, Karin Krumbach, Moritz-Fabian M üller, Bas Vroling, Philana V. van Summeren-Wesenhagen, Stephan Noack and Jan Marienhagen Tags: Research article Source Type: research