Sarcoidosis-Associated Pulmonary Hypertension

Pulmonary hypertension is a life-threatening complication of advanced sarcoidosis. Many mechanisms can cause an elevation of pulmonary pressure in sarcoidosis, leading to precapillary or postcapillary pulmonary hypertension. Sarcoidosis-associated pulmonary hypertension contributes to severe exertional dyspnea, reduced exercise capacity, and notably compromised the survival. Despite the critical functional and prognostic implications of pulmonary hypertension in sarcoidosis, there is a scarcity of specific guidelines on the management of these patients due to a lack of evidence. Hence, further research is required to identify subgroups of patients who may benefit from pulmonary arterial hypertension-targeted therapies and/or immunosuppressive therapies.

Source: Clinics in Chest Medicine - September 1, 2023 Category: Respiratory Medicine Authors: Laurent Savale, Peter Dorfm üller, Athénaïs Boucly, Xavier Jaïs, Thomas Lacoste-Palasset, Mitja Jevnikar, Andrei Seferian, Marc Humbert, Olivier Sitbon, David Montani Source Type: research