The virus-induced cyclic dinucleotide 2 ′3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila

In the model organism Drosophila melanogaster, two cGAS-like receptors participate in antiviral host-defense. Cai et  al. explore STING-dependent immunity in several Drosophila species and report that flies encode up to seven cGAS-like receptors, which can produce distinct cyclic dinucleotide signals in response to viral infection.

Source: Immunity - September 1, 2023 Category: Allergy & Immunology Authors: Hua Cai, Lihua Li, Kailey M. Slavik, Jingxian Huang, Ting Yin, Xianlong Ai, L éna Hédelin, Gabrielle Haas, Zhangmin Xiang, Yunyun Yang, Xiaoyan Li, Yuqiang Chen, Ziming Wei, Huimin Deng, Di Chen, Renjie Jiao, Nelson Martins, Carine Meignin, Philip J. Kr Tags: Article Source Type: research