A clinicopathological and immunohistochemical profile of primary extra mammary paget & #39;s Disease in skin of colour: A case series

Subhra Dhar, Divya Gupta, Aditi Chakraborty, Rajib Malakar, Sandipan DharIndian Journal of Dermatology 2023 68(4):488-488 Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been described here. While a well-defined persistent plaque with crusting and erosion was the most common presentation, hyperpigmentation, hypopigmentation and depigmentation were also observed in two patients. Characteristic Paget's cells with cytokeratin 7 and EMA positivity were seen on histopathology examination. Authors conclude that pigmentary alterations may be under-reported in extra mammary Paget's disease in the skin of colour.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research