The Role of Extracellular Vesicles on the Occurrence of Clinical Complications in β-Thalassemia

Thalassemia is a heterogeneous group of hereditary quantitative hemoglobinopathies caused by partial or complete defects in the synthesis of globin chains [1]. According to the type of globin chain with defective synthesis, thalassemia is classified into α-, β-, δβ-, γδβ-, δ- and γ-thalassemia (γ-thal) types. α- and β-thal are the most common types of thalassemia, which are caused by defects in the synthesis of α-globin and β-globin chain genes, respectively [2]. The main pathophysiology of thalassemia is the decrease in the synthesis of globin chains and the imbalance of the ratio of globin chains in Hb.

Source: Experimental Hematology - August 29, 2023 Category: Hematology Authors: Mehrnaz Abdolalian, Mahin Nikogouftar Zarif, Mohammadreza Javan Tags: Review Article Source Type: research