A Biaryl-Cyclohexenone Photoelectrocyclization/Dearomatization Sequence to Substituted Terpenes

Tetrahedron. 2023 Jan 26;131:133180. doi: 10.1016/j.tet.2022.133180. Epub 2022 Dec 10.ABSTRACTDescribed here is the development of sequential cross-coupling, photoelectrocyclizations, and reductive dearomatizations of biaryl cyclohexenones as a means of synthesizing terpene skeletons. This methodology promises to provide insight that will enable us and others to use this approach to generate a variety of biologically active small molecules, including members of the abietane and morphinan skeletons.PMID:37593114 | PMC:PMC10430876 | DOI:10.1016/j.tet.2022.133180

Source: Tetrahedron - August 18, 2023 Category: Chemistry Authors: K S Satyanarayana Tummalapalli Xuchen Zhao Jon D Rainier Source Type: research