Cover Image

Metastable conformational states of the phosphodiesterase 5 (PDE5) enzyme are shown in the apo state (leftmost panels) and two inhibitor-bound states, the allosteric inhibitor evodiamine-bound PDE5 (middle panels), and the competitive inhibitor avanafil-bound PDE5 (rightmost panels). The conformational states correspond to minima in the free energy surfaces (top panels) labeled with blue, orange, and red dots. For details, see: Shubhandra Tripathi et al.,Protein Science, 2023.https://doi.org/10.1002/pro.4720

Source: Protein Science - August 22, 2023 Category: Biochemistry Tags: Cover Image Source Type: research