Cancers, Vol. 15, Pages 4196: Efficacy of Empirical Radioiodine Therapy in Patients with Differentiated Thyroid Cancer and Elevated Serum Thyroglobulin without Evidence of Structural Disease: A Propensity Score Analysis
Cancers, Vol. 15, Pages 4196: Efficacy of Empirical Radioiodine Therapy in Patients with Differentiated Thyroid Cancer and Elevated Serum Thyroglobulin without Evidence of Structural Disease: A Propensity Score Analysis
Cancers doi: 10.3390/cancers15164196
Authors:
Leandra Piscopo
Emilia Zampella
Fabio Volpe
Valeria Gaudieri
Carmela Nappi
Paolo Cutillo
Federica Volpicelli
Maria Falzarano
Leonardo Pace
Alberto Cuocolo
Michele Klain
We assessed the outcome of administration of empiric radioactive iodine (RAI) therapy to patients with differentiated thyroid cancer (DTC), in a propensity-score-matched cohort of patients with biochemical incomplete response (BIR) and without evidence of structural disease. We retrospectively evaluated 820 DTC patients without distant metastases, who underwent total thyroidectomy followed by RAI therapy, with available BIR at 12 months and follow-up evaluations. The patients were categorized according to the administration of empiric therapy (ET). To account for differences between patients with (n = 119) and without (n = 701) ET, a propensity-score-matched cohort of 119 ET and 119 no-ET patients was created. The need for additional therapy and the occurrence of structural disease were considered as end-points. During a median follow-up of 53 months (range 3–285), 57 events occurred (24% cumulative event rate). The rate of events was significantly higher in the no-ET compared to the ET patients (30% vs. 18%...
Source: Cancers - Category: Cancer & Oncology Authors: Leandra Piscopo Emilia Zampella Fabio Volpe Valeria Gaudieri Carmela Nappi Paolo Cutillo Federica Volpicelli Maria Falzarano Leonardo Pace Alberto Cuocolo Michele Klain Tags: Article Source Type: research
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