A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor α determines T cell activation and function

Nuclear retinoic acid receptor alpha (RAR α) regulates gene transcription upon the binding of retinoic acid (RA). Larange, Takazawa, Kakugawa, Thiault et al. identify an RARα isoform in the cytoplasm of T cells (cRARα) and reveal that cRARα binds the TCR-ZAP-70 complex, thereby regulating T cell proliferation and effector differentia tion. RA counteracts TCR-engaged RARα, resulting in suboptimal TCR activation but enhanced Treg cell differentiation.

Source: Immunity - August 18, 2023 Category: Allergy & Immunology Authors: Alexandre Larange, Ikuo Takazawa, Kiyokazu Kakugawa, Nicolas Thiault, SooMun Ngoi, Meagan E. Olive, Hitoshi Iwaya, Laetitia Seguin, Ildefonso Vicente-Suarez, Stephane Becart, Greet Verstichel, Ann Balancio, Amnon Altman, John T. Chang, Ichiro Taniuchi, Bj Tags: Article Source Type: research