Human microglia maturation is underpinned by specific gene regulatory networks

Molecular mechanisms that drive human microglia diversity remain largely unknown. Han and Li et  al. characterize transitions in the transcriptomes and epigenomes of human fetal and postnatal microglia, develop computational tools that predict underlying gene regulatory networks, and demonstrate that core features of these networks can be captured by iPSC-derived microglia.

Source: Immunity - August 14, 2023 Category: Allergy & Immunology Authors: Claudia Z. Han, Rick Z. Li, Emily Hansen, Samantha Trescott, Bethany R. Fixsen, Celina T. Nguyen, Cristina M. Mora, Nathanael J. Spann, Hunter R. Bennett, Olivier Poirion, Justin Buchanan, Anna S. Warden, Bing Xia, Johannes C.M. Schlachetzki, Martina P. P Tags: Resource Source Type: research