Age-related differences in associative memory recognition of Chinese characters and hippocampal subfield volumes

Biol Psychol. 2023 Aug 8:108657. doi: 10.1016/j.biopsycho.2023.108657. Online ahead of print.ABSTRACTAssociative memory is a type of hippocampal-dependent episodic memory that declines with age. Studies have examined the neural substrates underlying associative memory and considered the hippocampus holistically; however, the association between associative memory decline and volumetric change in hippocampal subfields in the context of normal aging remains uncharacterized. Leveraging the distinct linguistic features of Chinese characters to evaluate distinct types of false recognition, we investigated age-related differences in associative recognition and hippocampal subfield volumes, as well as the relationship between behavioral performance and hippocampal morphometry in 25 younger adults and 32 older adults. The results showed an age-related associative memory deficit, which was exacerbated after a 30-min delay. Older adults showed higher susceptibility to false alarm errors with recombined and orthographically related foils compared to phonologically or semantically related ones. Moreover, we detected a disproportionately age-related, time-dependent increase in orthographic errors. Older adults exhibited smaller volumes in all hippocampal subfields when compared to younger adults, with a less pronounced effect observed in the CA2/3 subfield. Group-collapsed correlational analyses revealed associations between specific hippocampal subfields and associative memory but not it...
Source: Biological Psychology - Category: Psychiatry & Psychology Authors: Source Type: research