Loss of CD4+ T  cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

West et  al. demonstrate that CD4+ T cell-intrinsic arginase 1 paces the transition of Th1 cells from their induction to their contraction program via balancing glutamine vs. arginine usage. They further show that Th1 cells lacking arginase 1 retain full pathogen clearance capacity but cause less Th1-asso ciated tissue pathology.

Source: Immunity - August 11, 2023 Category: Allergy & Immunology Authors: Erin E. West, Nicolas S. Merle, Marcin M. Kami ński, Gustavo Palacios, Dhaneshwar Kumar, Luopin Wang, Jack A. Bibby, Kirsten Overdahl, Alan K. Jarmusch, Simon Freeley, Duck-Yeon Lee, J. Will Thompson, Zu-Xi Yu, Naomi Taylor, Marc Sitbon, Douglas R. Green Tags: Article Source Type: research