Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Conclusions c-Fos modulates cellular bioenergetics in chondrocytes by balancing pyruvate flux between anaerobic glycolysis and the tricarboxylic acid cycle in response to OA signals. We identify a novel metabolic adaptation of chondrocytes controlled by c-Fos-containing AP-1 dimers that could be therapeutically relevant.
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Open access, ARD, Animal models Source Type: research