SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals

How infection by a viral variant showing antigenic drift impacts a preformed mature human memory B cell (MBC) repertoire remains unclear. Sokal et  al. show that SARS-CoV-2 Omicron BA.1 breakthrough infections induce late remodeling and maturation of the pre-existing memory B cell pool, with progressively improved MBC affinity and neutralization breadth but limited recruitment of BA.1-restricted naive B cells.

Source: Immunity - August 4, 2023 Category: Allergy & Immunology Authors: Aur élien Sokal, Giovanna Barba-Spaeth, Lise Hunault, Ignacio Fernández, Matteo Broketa, Annalisa Meola, Slim Fourati, Imane Azzaoui, Alexis Vandenberghe, Pauline Lagouge-Roussey, Manon Broutin, Anais Roeser, Magali Bouvier-Alias, Etienne Crickx, Laetit Tags: Article Source Type: research