Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

Zhao et  al. performed phenotypic CRISPR screens to uncover genes and pathways that suppress spontaneous and DNA replication stress-associated DNA damage in human cells. Among the identified genes, GNB1L, which is deleted in the 22q11.2 syndrome, is essential for the biosynthesis of kinases of the ATM/ATR family.

Source: Molecular Cell - July 20, 2023 Category: Cytology Authors: Yichao Zhao, Daniel Tabet, Diana Rubio Contreras, Linjiang Lao, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Sumin Feng, Atina G. Cot é, Zhen-Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne-Claude Gingras, Fernando Gómez Herreros, Fre Tags: Resource Source Type: research