High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes

We systematically identified 876 functional SNPs associated with insulin resistance-relevant phenotypes and prioritized 102 candidate target genes by multi-omics analyses. Specifically, we decrypted the genetic regulatory mechanism underlying IRS1 locus. Based on the STARR-seq data, we predicted the regulatory activities of over 200,000 noncoding SNPs and developed an open resource.

Source: The American Journal of Human Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: Yuan-Yuan Duan, Xiao-Feng Chen, Ren-Jie Zhu, Ying-Ying Jia, Xiao-Ting Huang, Meng Zhang, Ning Yang, Shan-Shan Dong, Mengqi Zeng, Zhihui Feng, Dong-Li Zhu, Hao Wu, Feng Jiang, Wei Shi, Wei-Xin Hu, Xin Ke, Hao Chen, Yunlong Liu, Rui-Hua Jing, Yan Guo, Meng Tags: Article Source Type: research