Re-visitation of Two Models for Predicting Mechanically-Induced Disordering after Cryogenic Impact Milling

ConclusionsPrediction accuracy of the ρcrit model decreased with dataset expansion, relative to previously published results. Overall, the ρcrit model was considerably less accurate relative to the bivariate empirical model, which retained very high prediction accuracy for the expanded dataset. Although the empirical model does not imply a mechanism, model robustness suggests the importance of glass transition temperature (Tg) and molar volume (Mv) on formation and persistence of amorphous materials following extensive cryomilling.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research