Detection of a natural antibody targeting the shed ectodomain of BP180 in mice

Pemphigoid diseases are characterized by subepidermal blister formation accompanied by autoantibodies targeting skin component molecules, such as BP180. It is suggested that an epitope –phenotype correlation exists among autoantibodies recognizing BP180. However, it is unclear which regions of BP180 are likely targets for autoantibodies.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research