Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery

Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726151607. Online ahead of print.ABSTRACTBecause of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties and potential as vehicles to deliver different drugs.PMID:37496133 | DOI:10.2174/1567201820666230726151607
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research