d-Serine as a sensor and effector of the kidney

Abstractd-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level ofd-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance.d-Serine also has a direct effect on the kidneys and mediates the cellular proliferation of tubular cells via mTOR signaling and induces kidney remodeling as a compensatory reaction to the loss of kidney mass. In living kidney donors, the removal of the kidney results in an increase in bloodd-serine level, which in turn accelerates kidney remodeling and augments kidney clearance, thus reducing blood levels ofd-serine. This feedback system strictly controlsd-serine levels in the body. The function ofd-serine as a biomarker and modulator of kidney function will be the basis of precision medicine for kidney diseases.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research