Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis

Invasive candidiasis has high mortality rates with limited therapeutic options. Gander-Bui et  al. show how macrophage-secreted IL-1 receptor antagonist (IL-1Ra) restricts recruitment of fungicidal neutrophils and drives candidiasis pathology. Therapeutic IL-1Ra neutralization protects against lethal Candida sepsis; however, interferon-driven amplification of IL-1Ra during viral infection e xacerbates fungal dissemination and disease.

Source: Immunity - July 20, 2023 Category: Allergy & Immunology Authors: Hang Thi Thuy Gander-Bui, Jo ëlle Schläfli, Johanna Baumgartner, Sabrina Walthert, Vera Genitsch, Geert van Geest, José A. Galván, Carmen Cardozo, Cristina Graham Martinez, Mona Grans, Sabine Muth, Rémy Bruggmann, Hans Christian Probst, Cem Gabay, St Tags: Article Source Type: research