Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents

An optimization strategy was adopted for designing and synthesizing new series of 2-oxindole conjugates. Selected compounds were evaluated for their antiproliferative effect in vitro against NCI-60 cell lines ...

Source: Chemistry Central Journal - July 18, 2023 Category: Chemistry Authors: Rania S. M. Ismail, Ahmed M. El Kerdawy, Dalia H. Soliman, Hanan H. Georgey, Nagwa M. Abdel Gawad, Andrea Angeli and Claudiu T. Supuran Tags: Research Source Type: research