Determinants of adherence to daily PrEP measured as intracellular tenofovir diphosphate concentrations over 24 months of follow-up among men who have sex with men

Conclusions
Overall, TFV-DP concentrations were high among MSM using dPrEP, indicating excellent adherence. Especially older participants, those who reported condomless anal sex with a casual partner prior to PrEP initiation and those who used an app with visualised feedback showed higher levels of adherence. As TFV-DP concentrations had decreased slightly at 2 years of PrEP use when compared with 1 year, we emphasise the importance of adherence counselling to those who continue using PrEP.

Trial registration number
NL5413.

Source: Sexually Transmitted Infections - July 17, 2023 Category: Sexual Medicine Authors: van den Elshout, M. A., Hoornenborg, E., Coyer, L., Anderson, P. L., Davidovich, U., de Vries, H. J., Prins, M., Schim van der Loeff, M. F., On behalf of of the Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative (H-TEAM) Tags: Open access Original research Source Type: research