Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia

In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower ...

Source: Journal of NeuroEngineering and Rehabilitation - July 15, 2023 Category: Rehabilitation Authors: Christian Lassmann, Winfried Ilg, Tim W. Rattay, Ludger Sch öls, Martin Giese and Daniel F. B. Haeufle Tags: Research Source Type: research