Elucidation of the mechanism of amyloid A and transthyretin formation using mass spectrometry-based absolute quantification

In this study, the process of transthyretin from an 'early fibril state' consisting of full-length ATTR to a 'mature ATTR amyloid fibril' with a truncated low-amyloidogenic segment has been mathemat ically revealed. The amount of full-length ATTR was nine times higher than in mature fibers. Large cohort studies using MS-QBIC may shed light on the clinical significance of amyloid fibrils.

Source: Virchows Archiv - July 15, 2023 Category: Pathology Source Type: research