Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging

Annu Rev Immunol. 2023 Apr 26;41:181-205. doi: 10.1146/annurev-immunol-101721-064501.ABSTRACTThere is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.PMID:37126417 | DOI:10.1146/annurev-immunol-101721-064501

Source: Annual Review of Immunology - May 1, 2023 Category: Allergy & Immunology Authors: Gonzalo Soto-Heredero Manuel M G ómez de Las Heras J Ignacio Escrig-Larena Mar ía Mittelbrunn Source Type: research