Estimation of the preanalytical activation of the contact system in coagulation tubes

Preanalytical problems may interfere with or affect the determination of certain biochemical quantities and should preferably be avoided. It is well-known that glass tubes may activate the contact system and initiate coagulation. Therefore, tubes used for coagulation assays are either plastic tubes or glass tubes coated with an inert material, e.g., silicone. But some coagulation assays such as the thrombin generation assay which is activated and initiated by tissue factor (TF), are particularly sensitive to contact activation, especially at low TF concentrations (1).

Source: Thrombosis Research - July 11, 2023 Category: Hematology Authors: S øren Risom Kristensen, Jørgen Brodersen Gram, Jette Nybo, Johannes Jakobsen Sidelmann, Yaseelan Palarasah Tags: Letter to the Editors-in-Chief Source Type: research