Copper-catalyzed N-arylation of amines with aryliodonium ylides in water

Abstract Copper sulfate catalyzed an efficient, inexpensive, and environment-friendly protocol that has been developed for N-arylation of amines with 1,3-cyclohexadione-derived aryliodonium ylides in water as a green solvent. Aromatic primary amines substituted with electron-donating as well as electron-withdrawing groups on the aryl ring reacted smoothly with iodonium ylides to give the corresponding diarylamines with good to excellent yields. Also, secondary amines underwent N-arylation to deliver tertiary amines with moderate yields. Beilstein J. Org. Chem. 2023, 19, 1008–1014. doi:10.3762/bjoc.19.76
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: amines arylation C – N bond formation iodonium ylide sustainable Letter Source Type: research