Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice

CONCLUSIONS: Pxt1 induces cell death; thus, the higher sperm DFI of mice with targeted deletion of Pxt1 suggests some function for this gene in the elimination of male germ cells with chromatin damage.IMPLICATIONS: Ablation of mouse Pxt1 results in enhanced DFI. In humans, the homologous PXT1 gene shares 74% similarity with the mouse gene; thus, it can be considered a candidate for mutation screening in patients with increased DFI.PMID:37393946 | DOI:10.1071/RD23061

Source: Reproduction, Fertility, and Development - July 2, 2023 Category: Reproduction Medicine Authors: Bernadetta Pawlicka Micha ł Duliban Mateusz Zi ęba Micha ł Bochenek Kamila Zi ęba Ibrahim Adham Maja Studencka-Turski Andreas Meinhardt Pawe ł Grzmil Source Type: research