NLRP3  activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

CONCLUSIONS: Macrophage activation may be essential for NEC development. NLRP3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development, and all these may be therapeutic targets for developing treatments for NEC.PMID:37389784 | DOI:10.1007/s12519-023-00727-5

Source: World Journal of Pediatrics : WJP - June 30, 2023 Category: Pediatrics Authors: Bo Shi Cheng-Jie Lyu Zhen-Kai Le Hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang Huang Lin-Jun Yu Qiang Shu Jin-Fa Tou Deng-Ming Lai Source Type: research