[ASAP] Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS < sup > G12C < /sup > with Demonstrable CNS Penetration

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00746

Source: Journal of Medicinal Chemistry - July 3, 2023 Category: Chemistry Authors: Jason G. Kettle, Sharan K. Bagal, Derek Barratt, Michael S. Bodnarchuk, Scott Boyd, Erin Braybrooke, Jason Breed, Doyle J. Cassar, Sabina Cosulich, Michael Davies, Nichola L. Davies, Chao Deng, Andrew Eatherton, Laura Evans, Lyman J. Feron, Shaun Fillery, Source Type: research