Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SO2F2)

Abstract
A SO2F2-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with (E)-configuration selectivity. This new method features wide substrate scope, mild conditions, and direct N–O activation.

Beilstein J. Org. Chem. 2023, 19, 901–908. doi:10.3762/bjoc.19.68

Source: Beilstein Journal of Organic Chemistry - June 22, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: direct N – O activation E-selectivity nitrile synthesis ring-opening cross-coupling sulfuryl fluoride SO2F2 Letter Source Type: research