Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa?

Nature Reviews Endocrinology, Published online: 14 June 2023; doi:10.1038/s41574-023-00863-yCase studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinaemia induced by loss of adipose tissue mass might trigger psychological changes observed in starvation. Accordingly, leptin analogues might prove beneficial for treatment of anorexia nervosa.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research