Response to: 'Correspondence on 'Efficacy and safety of brodalumab, an anti-IL17RA monoclonal antibody, in patients with axial spondyloarthritis: 16-week results from a randomised, placebo-controlled, phase 3 trial by Zhao and Huang

We thank Dr Zhao and Dr Huang for their interest in our article.1 2 The approved dosage of brodalumab for plaque psoriasis includes a loading treatment of 210 mg every week at weeks 0, 1 and 2 followed by a dose of 210 mg every 2 weeks thereafter.3 The brodalumab dosage administered in patients with axial spondyloarthritis (axSpA) in our study1 was the same as that approved for plaque psoriasis. Therefore, the rapid improvement in Assessment of SpondyloArthritis International Society 40/20 as early as week 2 in patients with axSpA in our study and similar to the improvement observed in Psoriasis Area and Severity Index in patients with plaque psoriasis4 could be attributed to the loading treatment. However, the study5 that Zhao et al have referred to in their correspondence2 was conducted in patients with psoriatic arthritis...
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: ARD Correspondence response Source Type: research