Role of mouse dendritic cell subsets in priming naive CD4 T cells

Curr Opin Immunol. 2023 Jun 3;83:102352. doi: 10.1016/j.coi.2023.102352. Online ahead of print.ABSTRACTConventional dendritic cells (cDCs) are potent antigen-presenting cells that consist of developmentally, phenotypically, and functionally distinct subsets. Following immunization, each subset of cDCs acquires the antigen and presents it to CD4T (CD4+ T (cells)) cells with distinct spatiotemporal kinetics in the secondary lymphoid organs, often causing multiple waves of antigen presentation to CD4T cells. Here, we review the current understanding of the kinetics of antigen presentation by each cDC subset and its functional consequences in priming naive CD4T cells, and discuss its implications in the differentiation of CD4T cells.PMID:37276821 | DOI:10.1016/j.coi.2023.102352
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Source Type: research