B-cell capacity for expansion and differentiation into plasma cells are altered in osteoarthritis

Autoantibody (autoAbs) production in osteoarthritis (OA), coupled with evidence of disturbed B-cell homeostasis, suggest a potential role for B-cells in OA. B-cells can differentiate with T-cell help (T-dep) or using alternative TLR co-stimulation (TLR-dep). We analysed the capacity for differentiation of B-cells in OA versus age-matched heathy controls and compared the capacity of OA synovitis-derived stromal cells to provide support for plasma cell maturation.

Source: Osteoarthritis and Cartilage - June 6, 2023 Category: Rheumatology Authors: Xuanxiao Xie, Gina M. Doody, Farag Shuweihdi, Philip G. Conaghan, Frederique Ponchel Source Type: research