Alkaloids from the stems of < em > Fissistigma maclurei < /em > Merr. inhibit the proliferation of synoviocytes

Nat Prod Res. 2023 May 31:1-7. doi: 10.1080/14786419.2023.2218006. Online ahead of print.ABSTRACTTwo new aporphine-derived alkaloids, aporaloids C and D (1 and 2), along with eight known biogenetically related alkaloids (3-10) were isolated from the stems of Fissistigma maclurei Merr. Their structures were elucidated by detailed analysis of NMR, HRESIMS, MS, IR, UV and Optical rotations data. Compounds 1 and 2 represent a rare example of N-methylol aporphine-derived alkaloids from natural sources. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed potent inhibitory effect on the proliferation of synoviocytes with an IC50 value of 4.8 μM. Compounds 1, 2, 6-9 and 10 exhibited moderate inhibitory activity on synoviocytes, with IC50 values of 36.8, 37.1, 31.2 μM, 32.5, 36.3, 36.8 and 18.2 μM, respectively.PMID:37254867 | DOI:10.1080/14786419.2023.2218006

Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Mu-Tao Liang Xiao-Zheng Zhang Zi-Hao Chen Chuan-Shan Fu Duo-Jiang Li Guo-Ze Chen Ji-Ling Yi Xue-Ming Zhou Source Type: research