[ASAP] Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3 ‑ < italic toggle="yes" > d < /italic > ]pyrimidine Derivatives as Human Immunodeficiency Virus ‑1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00275

Source: Journal of Medicinal Chemistry - May 31, 2023 Category: Chemistry Authors: Zhao Wang, Prem Prakash Sharma, Brijesh Rathi, Minghui Xie, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, and Xinyong Liu Source Type: research