Extensive ITR expansion of the 2022 Mpox virus genome through gene duplication and gene loss

We describe duplications of up to 18,200 bp to the opposed genome end, and deletions at the site of insertion of up to 16,900 bp. Deletions and duplications of genes with functions of supposed immune modulation, virulence and host adaption as B19R, B21R, B22R and D10L are described. In summary, we highlight the need for monito ring rearrangements of the Mpox virus genome rather than for monitoring single mutations only.
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research