Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke – Blackburn – Bienaym é and Ugi reactions

Abstract Peptidomimetics with a substituted imidazo[1,2-a]pyridine fragment were synthesized by a tandem of Groebke–Blackburn–Bienaymé and Ugi reactions. The target products contain substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores with four diversity points introduced from readily available starting materials, including scaffold diversity. A small focused compound library of 20 Ugi products was prepared and screened for antibacterial activity. Beilstein J. Org. Chem. 2023, 19, 727–735. doi:10.3762/bjoc.19.53
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: Groebke – Blackburn Bienaym é reaction imidazo[1,2-a]pyridine isocyanide multicomponent reaction peptidomimetic Ugi reaction Full Research Paper Source Type: research