Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach

The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physical stability and obtain pharmaceutical applications such as hydrogels...

Source: Journal of Biological Engineering - May 23, 2023 Category: Biotechnology Authors: Sergio A. Bernal-Ch ávez, Alejandra Romero-Montero, Héctor Hernández-Parra, Sheila I. Peña-Corona, María L. Del Prado-Audelo, Sergio Alcalá-Alcalá, Hernán Cortés, Lashyn Kiyekbayeva, Javad Sharifi-Rad and Gerardo Leyva-Gómez Tags: Review Source Type: research