Profiles of plasma interleukin-6 and interleukin-10 in relation to some haematologic alterations following colo-peritoneo-cystoplasty in dogs

AbstractSystemic inflammatory response to surgical interventions has been characterized by an orchestrated interplay of endogenous mediatory cytokines and haematologic alterations. The study was carried out to determine the changes in plasma levels of pro-inflammatory interleukin-6 (IL-6) and anti-inflammatory interleukin-10 (IL-10) in relation to haematological alterations in response to colo-peritoneo-cystoplasty in dogs. Haematological and plasma concentrations of IL-6 and IL-10 were profiled in four apparently healthy dogs, following the colo-peritoneo-cystoplastic procedure. Mean packed cell volume (PCV) significantly (P <  0.05) decreased from the pre-surgical 45.84 ± 3.67 to a lowest value (33.50 ± 2.53%) on day 7 post-surgery. Mean total leukocyte count (TLC) significantly (P <  0.05) increased from the pre-surgical value (9.85 ± 1.02 × 109/L) to a peak level (14.20  ± 2.77 × 109/L) on day 7 post-surgery. Mean neutrophil count significantly (P <  0.05) increased from the pre-surgical value of 6.63 ± 0.79 to a peak day 7 post-surgical value (10.00 ± 2.39 × 109/L. Mean lymphocyte count rose from 3.59  ± 0.31 to day 4 post-surgical value of 4.42 ± 0.82 × 109/L. Changes in mean eosinophil and monocyte counts were not significant (P >  0.05). Mean plasma IL-6 concentration significantly (P <  0.05) increased from 7639.45 ± 146.81 (pre-surgical) to 7916.62 ± 32.97 pg/mL...

Source: Comparative Clinical Pathology - May 19, 2023 Category: Pathology Source Type: research