Po-03-135 left atrial appendage occlusion versus standard of care in patients with atrial fibrillation and a prior thrombo-embolic event despite oral anticoagulant therapy: a propensity score matched comparison

Patients with atrial fibrillation (AF) that suffer from ischemic stroke despite oral anticoagulant (OAC) therapy have a very high risk of recurrent stroke and better prevention strategies are needed. Left atrial appendage occlusion (LAAO) is a promising secondary prevention strategy that may provide mechanical protection. However, evidence showing effectiveness of LAAO in this population is scarce and the current international guidelines only consider LAAO in patients with a contra-indication for OAC.

Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Moniek Maarse, David Seiffge, Errol Aarnink, Nicolai Fierro, Patrizio Mazzone, Alessandro Beneduce, Alessio Gasperetti, Claudio Tondo, Radek Pracon, Marcin Demkow, Kamil Zielinski, Ole de Backer, Kasper Korsholm, Jens Erik Nielsen-Kudsk, Rodrigo Estevez-L Source Type: research